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Capecitabine and docetaxel in treating the metastatic breast cancer Health Articles | November 27 Marvin Bagley III College Jersey , 2012
The effect of single drug treatment to metastatic breast cancer is not very well, in order to alleviate the symptoms, improve the quality of life and prolong the survival time, the main treatment method is combined with chemotherapy.

At present, docetaxel and capecitabine is highefficacy in treating advanced breast cancer drug, they combined medicationeffect is obvious Grant Hill College Jersey , is recognized as the preferred treatment options. Recentliterature reported, combined with the two drugs has significant advantagesthan single one of them, such as in the tumor remission rate, time to progressionand overall survival.

Breast cancer is the most common malignanttumor in female. Incidence in china shows ascendant trend. Data shows that, 5%-15%of breast cancer patients with clinically diagnosed had distant metastases, insome underdeveloped areas even up to 20%-25% Harry Giles College Jersey , for such patients, chemotherapyis the main treatment. Anthracycline chemotherapy drugs in breast cancer ischemotherapy based drug, and along with the clinical research and application,recent reports by docetaxelmanufacturer show that the combined application of docetaxel and capecitabineis most effective drugs following by anthracycline treating breast cancer afterfailure. Both combined with medicine can improve the curative effect, but noobvious adverse reaction increase.

Docetaxel belongs to paclitaxel drug, it isa semi-synthetic. Its mechanism is related to the free tubulin binding Jayson Tatum College Jersey , promotetubulin polymerization, and inhibition of its depolymerization. The results makeit stable, thereby blocking tumor cell mitosis, inhibition of tumor cellreplication, killing tumor cells, to achieve the antitumor effect Brandon Ingram College Jersey , so thecurrent of docetaxel in the treatment of metastatic breast cancer is one of themost effective drugs.

Capecitabine is pharmaceutical raw materials, approvedby FDA of a class in tumor cell activation, and oral fluorinated pyrimidine,after oral administration can be integrally through gastrointestinal tractmucosa absorption, after the 3 steps unique activation mechanisms, reach thetumor tissue after it is converted into 5-Fu cells and play toxic effect. Itsmechanism of action is in the S phase of the cell cycle of tumor cells J.J. Redick College Jersey , withhighly targeted, compared with 5-Fu its anticancer effect is enhanced, reducingside effect.

Capecitabine plus docetaxel therapy forbreast cancer is relatively good, especially after menopause and the ERreceptor and PR receptor positive patients is better. For anorexia, nausea,vomiting Quinn Cook College Jersey , may be rehydration, antiemetic therapy; elevated transaminases toliver transaminase, such treatment; for the neutropenic patients to colonystimulating factor after treatment, can be on time receiving chemotherapy andcan complete the entire course of chemotherapy; individual patients developedhand-foot syndrome, stomatitis, phlebitis Christian Laettner College Jersey , allergy, are improving after giventhe corresponding treatment.

To sum up, docetaxel combined withcapecitabine in treating metastatic breast cancer can achieve good curativeeffect in the near future, and the adverse reactions can be tolerated, can be controlledthrough corresponding methods, no treatment termination because of obviousadverse reactions. The combined application of the two drugs can improve thequality of patients? life Justise Winslow College Jersey , clinical tumor control rate is good, consistent withthe aim of treating advanced cancer.

Source:http:www.cospcn
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